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However, clinical data confirms that weight loss is significantly slower with microdosing compared to standard therapeutic doses, often resulting in much less total weight loss over the same period

The difficulty was that testing for low blood glucose necessitated laboratory equipment and technical skills that were then not available to most physicians

& Sturmer, T

Back Couzin-Frankel, J (14 Dec 2023) 'Obesity meets its match', Science

Design stacks with clear protocols for dosing, timing, cycling, start low, titrate to response, time around workouts and sleep, and off-cycle to minimize tolerance and long-term risk